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Effexor (Venlafaxine) is the first timoanaleptic of III generation (so-called double-acting - SNRI), after which there was a whole bulk of other drugs (milnacipran, duloxetine). It must be noted that Effexor - the most studied and most commonly prescribed drug from the group of SNRI and is used in many studies (to prove the efficacy of new antidepressants) as a reference.
In the world, Effexor has already established itself as a highly efficient in treatment such conditions as: generalized anxiety disorder, panic disorder, OCD, social phobia, posttraumatic stress disorder, depressive disorders in children and adolescents, tension headache and migraine, cocaine addiction, comorbidity with depressive disorders, attention deficit disorder, chronic pain, fibromyalgia.
In spite of the fact that Effexor is safe medication for all patients, before taking it, you should consider its precautions:
- Simultaneous use with MAO inhibitors;
- Myocardial infarction and unstable angina;
- Changes in blood pressure;
- Increased intraocular pressure, and angle-closure glaucoma;
- Manic states in history;
- Initially underweight;
- Kidney / liver failure;
- Age under 18 years (safety and efficacy not established).
There is evidence of pharmacoeconomic studies showing the benefit of cost-effectiveness of Effexor in comparison with other pharmacological groups of antidepressants, generic effexor xr cheap no prescription, the most important parameters are its safety and tolerability.
Basing on data from controlled clinical studies in recent years we can form an opinion, buy effexor 75mg online xl us on the situation and the therapeutic possibilities of venlafaxine in support of the accumulated practical experience of its application and buy effexor uk mexico online price order xr online pharmacy.
In vitro studies it has been showed that Effexor has virtually no affinity for opioid, benzodiazepine and phencyclidine receptors and glutamate N-methyl-D-aspartate (NMDA)-receptor. In experimental studies found no significant stimulation of the central nervous system (in rodents), and is not marked significant excitation or depressant effect on central nervous system (in primates). In clinical trials, Effexor didn't show cases of abuse.
The proof of Effexor effectiveness in a dose of 75mg/day was derived from placebo-controlled trials of outpatients with depressive disorders, each of which has proven the superiority of Effexor tablets compared with placebo. Results of an open trial of venlafaxine in a dose of 75-150mg in 300 depressed patients with general medical network showed that 75% of the responders took the drug at a dose of 75mg (minimal dose!).